The antiviral activities of artemisinin and artesunate

T Efferth, MR Romero, DG Wolf… - Clinical infectious …, 2008 - academic.oup.com
Traditional Chinese medicine commands a unique position among all traditional medicines
because of its 5000 years of history. Our own interest in natural products from traditional …

Human cytochrome P450 1, 2, 3 families as pharmacogenes with emphases on their antimalarial and antituberculosis drugs and prevalent African alleles

CR Chamboko, W Veldman, RB Tata… - International Journal of …, 2023 - mdpi.com
Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism

D Li, Y Chen, M Wan, F Mei, F Wang, P Gu, X Zhang… - Cell Host & Microbe, 2024 - cell.com
Acetaminophen overuse is a common cause of acute liver failure (ALF). During ALF, toxins
are metabolized by enzymes such as CYP2E1 and transformed into reactive species …

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1 …

Y Wang, Y Jiang, X Fan, H Tan, H Zeng, Y Wang… - Toxicology letters, 2015 - Elsevier
Resveratrol (RES) has been shown to possess many pharmacological activities including
protective effect against liver damage induced by hepatotoxins. In the present study, the …

Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation

Y Jiang, X Fan, Y Wang, H Tan, P Chen, H Zeng… - Chemico-biological …, 2015 - Elsevier
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra fructus is widely-used traditional Chinese medicine which possesses …

A cocktail approach for assessing the in vitro activity of human cytochrome P450s: an overview of current methodologies

D Spaggiari, L Geiser, Y Daali, S Rudaz - Journal of pharmaceutical and …, 2014 - Elsevier
An assessment of cytochrome P450 (CYP) enzyme activity is essential for characterizing the
phase I metabolism of biological systems or to evaluate the inhibition/induction properties of …

Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques–state of the art in natural product HPLC-MS, HPLC …

C Seger, S Sturm, H Stuppner - Natural product reports, 2013 - pubs.rsc.org
Covering: 2005 to 2013Current natural product research is unthinkable without the use of
high resolution separation techniques as high performance liquid chromatography or …

[HTML][HTML] Biological fate and interaction with cytochromes P450 of the nanocarrier material, D-α-tocopheryl polyethylene glycol 1000 succinate

T Ren, R Li, L Zhao, JP Fawcett, D Sun, J Gu - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Abstract d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-
TPGS) is a biodegradable amphiphilic polymer prepared by esterification of vitamin E with …

Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration

Y Jiang, X Fan, Y Wang, P Chen, H Zeng… - Toxicological …, 2015 - academic.oup.com
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver
failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and …

Evaluation of metabolism-mediated herb-drug interactions

DH Na, HY Ji, EJ Park, MS Kim, KH Liu… - Archives of pharmacal …, 2011 - Springer
As the use of herbal medicines increases, the public health consequences of drug-herb
interactions are becoming more significant. Herbal medicines share the same drug …