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Engineering the next generation of cell-based therapeutics
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …
intractable diseases through uniquely powerful modes of action. Despite notable recent …
Microneedle system for tissue engineering and regenerative medicine
Global increasing demand for high life quality and length facilitates the development of
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …
Improved pharmacodynamics of epidermal growth factor via microneedles-based self-powered transcutaneous electrical stimulation
Epidermal growth factor is an excellent drug for promoting wound healing; however, its
conventional administration strategies are associated with pharmacodynamic challenges …
conventional administration strategies are associated with pharmacodynamic challenges …
[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …
non-invasiveness, painless and simple administration, controllable drug delivery, and …
[HTML][HTML] Advanced nanocarrier-and microneedle-based transdermal drug delivery strategies for skin diseases treatment
F Qu, R Geng, Y Liu, J Zhu - Theranostics, 2022 - ncbi.nlm.nih.gov
Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a
global burden and affecting the world economy. Skin diseases severely impact the patients' …
global burden and affecting the world economy. Skin diseases severely impact the patients' …
Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway
Q Zhang, L Shi, H He, X Liu, Y Huang, D Xu, M Yao… - ACS …, 2022 - ACS Publications
Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …
Microneedles in drug delivery: progress and challenges
In recent years, an innovative transdermal delivery technology has attracted great interest for
its ability to distribute therapeutics and cosmeceuticals for several applications, including …
its ability to distribute therapeutics and cosmeceuticals for several applications, including …
Engineered mesenchymal stromal cell exosomes-loaded microneedles improve corneal healing after chemical injury
F Yu, X Zhao, Q Wang, PH Fang, L Liu, X Du, W Li… - ACS …, 2024 - ACS Publications
Corneal alkali burns represent a prevalent ophthalmic emergency with the potential to
induce blindness. The main contributing mechanisms include excessive inflammation and …
induce blindness. The main contributing mechanisms include excessive inflammation and …
Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease
Transdermal drug delivery provides convenient and pain-free self-administration for
personalized therapy. However, challenges remain in treating acute diseases mainly due to …
personalized therapy. However, challenges remain in treating acute diseases mainly due to …
Implantable electronic medicine enabled by bioresorbable microneedles for wireless electrotherapy and drug delivery
A combined treatment using medication and electrostimulation increases its effectiveness in
comparison with one treatment alone. However, the organic integration of two strategies in …
comparison with one treatment alone. However, the organic integration of two strategies in …