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[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent
SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …
[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
Pancreatic regulation of glucose homeostasis
PV Röder, B Wu, Y Liu, W Han - Experimental & molecular medicine, 2016 - nature.com
In order to ensure normal body function, the human body is dependent on a tight control of
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
its blood glucose levels. This is accomplished by a highly sophisticated network of various …
Beta cell hubs dictate pancreatic islet responses to glucose
NR Johnston, RK Mitchell, E Haythorne, MP Pessoa… - Cell metabolism, 2016 - cell.com
The arrangement of β cells within islets of Langerhans is critical for insulin release through
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
the generation of rhythmic activity. A privileged role for individual β cells in orchestrating …
Recent advances in incretin-based pharmacotherapies for the treatment of obesity and diabetes
The incretin hormone glucagon-like peptide-1 (GLP-1) has received enormous attention
during the past three decades as a therapeutic target for the treatment of obesity and type 2 …
during the past three decades as a therapeutic target for the treatment of obesity and type 2 …
Biology of incretins: GLP-1 and GIP
LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier
This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
DJ Drucker, MA Nauck - The Lancet, 2006 - thelancet.com
Summary Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates
insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite …
insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite …
The physiology of glucagon-like peptide 1
JJ Holst - Physiological reviews, 2007 - journals.physiology.org
Abstract Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in
the intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …
the intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …
The biology of incretin hormones
DJ Drucker - Cell metabolism, 2006 - cell.com
Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …
The role of incretins in glucose homeostasis and diabetes treatment
W Kim, JM Egan - Pharmacological reviews, 2008 - Elsevier
Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …
minutes after eating. One of their many physiological roles is to regulate the amount of …