Stable radicals and thermally robust high-spin di-and triradicals have emerged as important
organic materials due to their promising applications in diverse fields. New fundamental …

Covering: 2000 to 2022 Secondary metabolites are assembled by drawing off and
committing some of the flux of primary metabolic building blocks to sets of enzymes that …

Dynobactins are recently discovered ribosomally synthesized and post-translationally
modified peptide (RiPP) antibiotics that selectively kill Gram-negative pathogens by …

Radical S-adenosyl-l-methionine (SAM) enzymes catalyze radical mediated chemical
transformations notable for their diversity. The radical mediated reactions that take place in …

Reductive dehalogenases (RDases) are key enzymes involved in the degradation of
organohalide compounds. Despite extensive experimental and computational studies, the …

Near-infrared (NIR) fluorescence imaging technology (NIR-I region, 650–950 nm and NIR-II
region, 1000–1700 nm), with deeper tissue penetration and less disturbance from auto …

Spectinomycin is a dioxane-bridged, tricyclic aminoglycoside produced by Streptomyces
spectabilis ATCC 27741. While the spe biosynthetic gene cluster for spectinomycin has …

MoaA is one of the most conserved radical S-adenosyl-l-methionine (SAM) enzymes, and is
found in most organisms in all three kingdoms of life. MoaA contributes to the biosynthesis of …

Objectives To enhance the de novo synthesis of SAM, the effects of several key genes on
SAM synthesis were examined based on modular strategy, and the key genes were …

Radical S-adenosyl-L-methionine (rSAM) enzymes bind one or more Fe-S clusters and
catalyze transformations that produce complex and structurally diverse natural products …