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Alternative animal models of aging research
S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …
Neoteny, prolongation of youth: from naked mole rats to “naked apes”(humans)
VP Skulachev, S Holtze, MY Vyssokikh… - Physiological …, 2017 - journals.physiology.org
It has been suggested that highly social mammals, such as naked mole rats and humans,
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …
are long-lived due to neoteny (the prolongation of youth). In both species, aging cannot …
From humans to hydra: patterns of cancer across the tree of life
TAF Albuquerque, L Drummond do Val… - Biological …, 2018 - Wiley Online Library
Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …
mutations and grow out of control, invading other tissues and provoking discomfort …
Transcriptome mining extends the host range of the Flaviviridae to non-bilaterians
The flavivirids (family Flaviviridae) are a group of positive-sense RNA viruses that include
well-documented agents of human disease. Despite their importance and ubiquity, the …
well-documented agents of human disease. Despite their importance and ubiquity, the …
Specialized mechanoreceptor systems in rodent glabrous skin
J Walcher, J Ojeda‐Alonso, J Haseleu… - The Journal of …, 2018 - Wiley Online Library
Key points An ex vivo preparation was developed to record from single sensory fibres
innervating the glabrous skin of the mouse forepaw. The density of mechanoreceptor …
innervating the glabrous skin of the mouse forepaw. The density of mechanoreceptor …
Rapid molecular evolution of pain insensitivity in multiple African rodents
Noxious substances, called algogens, cause pain and are used as defensive weapons by
plants and stinging insects. We identified four previously unknown instances of algogen …
plants and stinging insects. We identified four previously unknown instances of algogen …
Social evolution in African mole-rats–a comparative overview
The African mole-rat superfamily are a unique group of subterranean rodents that are
remarkable for their adaptations to a subterranean lifestyle and their range in sociality …
remarkable for their adaptations to a subterranean lifestyle and their range in sociality …
Genomic structural variation is associated with hypoxia adaptation in high-altitude zokors
Zokors, an Asiatic group of subterranean rodents, originated in lowlands and colonized high-
elevational zones following the uplift of the Qinghai–Tibet plateau about 3.6 million years …
elevational zones following the uplift of the Qinghai–Tibet plateau about 3.6 million years …
Dietary diversification and specialization in neotropical bats facilitated by early molecular evolution
Dietary adaptation is a major feature of phenotypic and ecological diversification, yet the
genetic basis of dietary shifts is poorly understood. Among mammals, Neotropical leaf …
genetic basis of dietary shifts is poorly understood. Among mammals, Neotropical leaf …
Positive selection and inactivation in the vision and hearing genes of cetaceans
The transition to an aquatic lifestyle in cetaceans (whales and dolphins) resulted in a radical
transformation in their sensory systems. Toothed whales acquired specialized high …
transformation in their sensory systems. Toothed whales acquired specialized high …