The biology of mycobacteria is dominated by a complex cell envelope of unique composition
and structure and of exceptionally low permeability. This cell envelope is the basis of many …

Highlights•“Old” molecules and targets represent attractive start points.•Modern medicinal
chemistry is essential to convert a compound hit into a drug.•Nutritional flexibility makes …

Solute binding proteins (SBPs) are of central physiological relevance for prokaryotes. These
proteins present substrates to transporters, but they also stimulate different signal …

Simple Summary Mycobacterium tuberculosis is a bacterium of great medical importance
because it causes tuberculosis, a disease that affects millions of people worldwide. Two …

Securing novel, safe, and effective medicines to treat Mycobacterium tuberculosis remains
an elusive goal, particularly influenced by the largely impervious Mtb envelope that limits …

The Mycobacterium tuberculosis (Mtb) LpqY-SugABC ATP-binding cassette transporter is a
recycling system that imports trehalose released during remodeling of the Mtb cell-envelope …

Almost 3% of the proteins of Mycobacterium tuberculosis (M. tuberculosis), the main
causative agent of human tuberculosis, are lipoproteins. These lipoproteins are …

Background Mycobacterium tuberculosis, the etiological agent of tuberculosis, has at least
four ATP-Binding Cassette (ABC) transporters dedicated to carbohydrate uptake …

Tuberculosis, caused by Mycobacterium tuberculosis, claims∼ 1.5 million lives annually.
Effective chemotherapy is essential to control TB, however the emergence of drug-resistant …

Bile salts are secreted into the gastrointestinal tract to aid in the absorption of lipids. In
addition, bile salts show potent antimicrobial activity in part by mediating bacterial protein …