Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear
element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse …

Subretinal injection (SRI) is a widely used technique in retinal research and can be used to
deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such …

The mouse model of laser-induced choroidal neovascularization (LI-CNV) has been widely
used to study neovascular age-related macular degeneration; however, it still lacks a …

Steroid-induced glaucoma (SIG) is the most common adverse steroid-related effect on the
eyes. SIG patients can suffer from trabecular meshwork (TM) dysfunction, intraocular …

Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal
pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular …

Abstract Purpose P2X7 receptor (P2X7R) is a purinergic cation channel whose activation
has been linked with age-related macular degeneration (ARMD). Several nucleoside …

Inflammasome activation is implicated in diseases of aberrant angiogenesis such as age-
related macular degeneration (AMD), though its precise role in choroidal neovascularization …

Purpose: Subretinal injection (SRI) in mice is widely used in retinal research, yet the
learning curve (LC) of this surgically challenging technique is unknown. Methods: To …

Purpose: Rhegmatogenous retinal detachment (RRD) is a vision-threatening event that
benefits from surgical intervention. While awaiting surgical reattachment, irreversible …

Root causal gene expression levels-or root causal genes for short-correspond to the initial
changes to gene expression that generate patient symptoms as a downstream effect …