Triazole demonstrates distinctive physicochemical properties, characterized by weak
basicity, various dipole moments, and significant dual hydrogen bond acceptor and donor …

Human aldo-keto reductases (AKRs) catalyze the NADPH-dependent reduction of carbonyl
groups to alcohols for conjugation reactions to proceed. They are implicated in resistance to …

Human aldo-keto reductase family 1 member C3 (AKR1C3) is known as a hormone activity
regulator and prostaglandin F (PGF) synthase that regulates the occupancy of hormone …

Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms,
such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are …

Castration resistant prostate cancer (CRPC) remains androgen dependant despite castrate
levels of circulating testosterone following androgen deprivation therapy, the first line of …

Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-
hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as …

Background: Human dihydroorotate dehydrogenase (hDHODH, EC 1.3. 5.2), a
flavindependent mitochondrial enzyme involved in de novo pyrimidine biosynthesis, is a …

Human dihydroorotate dehydrogenase (h DHODH) catalyzes the rate-limiting step in de
novo pyrimidine biosynthesis, the conversion of dihydroorotate to orotate. h DHODH has …

Aldo–keto reductase (AKR) 1C3 catalyzes the synthesis of active androgens that promote
the progression of prostate cancer. AKR1C3 also contributes to androgen-independent cell …

Fenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …