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Extracellular matrix and its therapeutic potential for cancer treatment
J Huang, L Zhang, D Wan, L Zhou, S Zheng… - Signal transduction and …, 2021 - nature.com
The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …
crucial roles, including mechanical support, modulation of the microenvironment, and a …
The biology and function of fibroblasts in cancer
Among all cells, fibroblasts could be considered the cockroaches of the human body. They
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …
survive severe stress that is usually lethal to all other cells, and they are the only normal cell …
Thrombopoietin receptor agonists: ten years later
The two thrombopoietin receptor agonists (TPO-RA), eltrombopag and romiplostim, were
licensed in the US for treatment of immune thrombocytopenia (ITP) in 2008 and, since then …
licensed in the US for treatment of immune thrombocytopenia (ITP) in 2008 and, since then …
Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health
The human gastrointestinal tract is inhabited by a vast number of microorganisms that are
called as the microbiota. Each individual harbors a unique gut microbial composition, this …
called as the microbiota. Each individual harbors a unique gut microbial composition, this …
TGF-β1 signaling and tissue fibrosis
KK Kim, D Sheppard… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …
wound repair in many organs. However, the outcome of temporary extracellular matrix …
Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment
Transforming growth factor‐β (TGF‐β) and programmed death ligand 1 (PD‐L1) initiate
signaling pathways with complementary, nonredundant immunosuppressive functions in the …
signaling pathways with complementary, nonredundant immunosuppressive functions in the …
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells
Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
glioblastoma stem cells (GSCs) are resistant to all standard therapies. We showed that …
Tackling the cancer stem cells—what challenges do they pose?
Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …
study. Their properties and mechanisms of formation have become a major focus of current …
Emerging cytokine networks in colorectal cancer
Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
cancer (CRC), in which inflammation and antitumour immunity are key determinants of …
Multifaceted role of neuropilins in the immune system: potential targets for immunotherapy
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …