Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

The cerebral oxygen cascade includes three key stages:(a) convective oxygen delivery
representing the bulk flow of oxygen to the cerebral vascular bed;(b) diffusion of oxygen from …

The activation of tyrosine kinase receptor c-Met by hepatocyte growth factor (HGF) showed
an anti-apoptotic effect in numerous disease models. This study aimed to investigate the …

The population is ageing worldwide, thus increasing the burden of common age-related
disorders to the individual, society and economy. Cerebrovascular diseases (stroke …

The regulation and defence of intracellular pH is essential for homeostasis. Indeed,
alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) …

Key points We investigated the influence of arterial () with and without acutely elevated
arterial pH and bicarbonate ([HCO3–]) on cerebral blood flow (CBF) regulation in the …

The development of the endovascular thrombectomy (EVT) technique has revolutionized
acute stroke management for patients with large vessel occlusions (LVOs). The impact of …

Overweight represents a major issue in contemporary orthopaedic practice. A higher body
mass index (BMI) is associated with an increase of perioperative complications following …

Parkinson's disease (PD) is a common neurodegenerative disorder, yet little is known about
cerebral haemodynamics in this patient population. Previous studies assessing dynamic …

(1) Background: Larger blood pressure variability (BPv) in the first 3 h post-stroke onset
increases pathophysiological effects such as infarct size, and leads to greater risk of …