Carbon ion radiobiology

W Tinganelli, M Durante - Cancers, 2020 - mdpi.com
Simple Summary Radiotherapy with carbon ions has been used for over 20 years in Asia
and Europe and is now planned in the USA. The physics advantages of carbon ions …

Chromatin and the cellular response to particle radiation-induced oxidative and clustered DNA damage

JM Danforth, L Provencher… - Frontiers in Cell and …, 2022 - frontiersin.org
Exposure to environmental ionizing radiation is prevalent, with greatest lifetime doses
typically from high Linear Energy Transfer (high-LET) alpha particles via the radioactive …

Radiation‐sensitive dendrimer‐based drug delivery system

SY Wu, HY Chou, CH Yuh, SL Mekuria… - Advanced …, 2018 - Wiley Online Library
Combination of chemotherapy and radiotherapy is used to enhance local drug delivery
while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l …

Combination therapy with charged particles and molecular targeting: a promising avenue to overcome radioresistance

K Konings, C Vandevoorde, B Baselet… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy plays a central role in the treatment of cancer patients. Over the past decades,
remarkable technological progress has been made in the field of conventional radiotherapy …

Enhanced cytotoxic and genotoxic effects of gadolinium-doped ZnO nanoparticles on irradiated lung cancer cells at megavoltage radiation energies

M Zangeneh, HA Nedaei, H Mozdarani… - Materials Science and …, 2019 - Elsevier
The purpose of this study was to investigate the radiation dose enhancement effects of
gadolinium-doped zinc oxide nanoparticles (Gd-doped ZnO NPs) under the megavoltage …

Photobiomodulation leads to enhanced radiosensitivity through induction of apoptosis and autophagy in human cervical cancer cells

GE Djavid, B Bigdeli, B Goliaei, A Nikoofar… - Journal of …, 2017 - Wiley Online Library
The radiomodulatory effect of photobiomodulation (PBM) has recently been studied in
cancer cells. The aim of this study was to investigate cellular mechanisms involved in the X …

Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by …

P Chowdhury, P Dey, S Ghosh, A Sarma, U Ghosh - BMC cancer, 2019 - Springer
Background Carbon ion (12 C) radiotherapy is becoming very promising to kill highly
metastatic cancer cells kee** adjacent normal cells least affected. Our previous study …

[HTML][HTML] Validation and comparison of the therapeutic efficacy of boron neutron capture therapy mediated by boron-rich liposomes in multiple murine tumor models

CA Maitz, AA Khan, PJ Kueffer, JD Brockman… - Translational …, 2017 - Elsevier
Boron neutron capture therapy (BNCT) was performed at the University of Missouri
Research Reactor in mice bearing CT26 colon carcinoma flank tumors and the results were …

Combined effects of carbon ion radiation and PARP inhibitor on non-small cell lung carcinoma cells: Insights into DNA repair pathways and cell death mechanisms

P Dey, R Das, S Chatterjee, R Paul, U Ghosh - DNA repair, 2024 - Elsevier
The utilization of high linear energy transfer (LET) carbon ion (12 C-ion) in radiotherapy has
witnessed a notable rise in managing highly metastatic, recurrent, and chemo/radio-resistant …

Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation

M Césaire, U Ghosh, JB Austry, E Muller… - Journal of Bone …, 2019 - Elsevier
Chondrosarcoma is a malignant tumor that arises from cartilaginous tissue and is
radioresistant and chemoresistant to conventional treatments. The preferred treatment …