Computation through neural population dynamics

S Vyas, MD Golub, D Sussillo… - Annual review of …, 2020 - annualreviews.org
Significant experimental, computational, and theoretical work has identified rich structure
within the coordinated activity of interconnected neural populations. An emerging challenge …

Neural algorithms and circuits for motor planning

HK Inagaki, S Chen, K Daie… - Annual review of …, 2022 - annualreviews.org
The brain plans and executes volitional movements. The underlying patterns of neural
population activity have been explored in the context of movements of the eyes, limbs …

Cortical preparatory activity indexes learned motor memories

X Sun, DJ O'Shea, MD Golub, EM Trautmann, S Vyas… - Nature, 2022 - nature.com
The brain's remarkable ability to learn and execute various motor behaviours harnesses the
capacity of neural populations to generate a variety of activity patterns. Here we explore …

[HTML][HTML] A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang… - Cell, 2022 - cell.com
Motor behaviors are often planned long before execution but only released after specific
sensory events. Planning and execution are each associated with distinct patterns of motor …

Causal role of motor preparation during error-driven learning

S Vyas, DJ O'Shea, SI Ryu, KV Shenoy - Neuron, 2020 - cell.com
Current theories suggest that an error-driven learning process updates trial-by-trial to
facilitate motor adaptation. How this process interacts with motor cortical preparatory activity …

A neural basis of choking under pressure

AL Smoulder, PJ Marino, ER Oby, SE Snyder, H Miyata… - Neuron, 2024 - cell.com
Incentives tend to drive improvements in performance. But when incentives get too high, we
can" choke under pressure" and underperform right when it matters most. What neural …

Parallel movement planning is achieved via an optimal preparatory state in motor cortex

N Meirhaeghe, A Riehle, T Brochier - Cell Reports, 2023 - cell.com
How do patterns of neural activity in the motor cortex contribute to the planning of a
movement? A recent theory developed for single movements proposes that the motor cortex …

Estimating noise correlations across continuous conditions with Wishart processes

A Nejatbakhsh, I Garon… - Advances in Neural …, 2023 - proceedings.neurips.cc
The signaling capacity of a neural population depends on the scale and orientation of its
covariance across trials. Estimating this" noise" covariance is challenging and is thought to …

Movement preparation time determines movement variability

K Sutter, L Oostwoud Wijdenes… - Journal of …, 2021 - journals.physiology.org
Faster movements are typically more variable—a speed-accuracy trade-off known as Fitts'
law. Are movements that are initiated faster also more variable? Neurophysiological work …

High-fidelity musculoskeletal modeling reveals that motor planning variability contributes to the speed-accuracy tradeoff

M Al Borno, S Vyas, KV Shenoy, SL Delp - Elife, 2020 - elifesciences.org
A long-standing challenge in motor neuroscience is to understand the relationship between
movement speed and accuracy, known as the speed-accuracy tradeoff. Here, we introduce …