Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Mitochondrial function declines during ageing owing to the accumulation of deleterious
mitochondrial genomes and damage resulting from the localized generation of reactive …

The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

The mitochondrial network is not only required for the production of energy, essential
cofactors and amino acids, but also serves as a signaling hub for innate immune and …

The biological basis of human aging remains one of the greatest unanswered scientific
questions. Increasing evidence, however, points to a role for alterations in mitochondrial …

Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …