Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …

Rho GTPases regulate the transcription factor SRF via their ability to induce actin
polymerization. SRF activity responds to G actin, but the mechanism of this has remained …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …

Smooth muscle cells switch between differentiated and proliferative phenotypes in response
to extracellular cues, but the transcriptional mechanisms that confer such phenotypic …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Virtually all smooth muscle genes analyzed to date contain two or more essential binding
sites for serum response factor (SRF) in their control regions. Because SRF is expressed in …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …