Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature reviews …, 2023 - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach

G Targher, H Tilg, CD Byrne - The lancet Gastroenterology & …, 2021 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This
narrative Review provides an overview of the current literature to support the notion that …

Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence

Y Tan, Z Zhang, C Zheng, KA Wintergerst… - Nature Reviews …, 2020 - nature.com
The pathogenesis and clinical features of diabetic cardiomyopathy have been well-studied
in the past decade, but effective approaches to prevent and treat this disease are limited …

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

KV Swanson, M Deng, JPY Ting - Nature Reviews Immunology, 2019 - nature.com
Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

Obesity, hypertension, and cardiac dysfunction: novel roles of immunometabolism in macrophage activation and inflammation

AJ Mouton, X Li, ME Hall, JE Hall - Circulation research, 2020 - ahajournals.org
Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - ahajournals.org
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Cardioimmunology: the immune system in cardiac homeostasis and disease

FK Swirski, M Nahrendorf - Nature Reviews Immunology, 2018 - nature.com
The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

[HTML][HTML] Macrophages facilitate electrical conduction in the heart

M Hulsmans, S Clauss, L **ao, AD Aguirre, KR King… - Cell, 2017 - cell.com
Organ-specific functions of tissue-resident macrophages in the steady-state heart are
unknown. Here, we show that cardiac macrophages facilitate electrical conduction through …

Single-cell transcriptional profiling reveals cellular diversity and intercommunication in the mouse heart

DA Skelly, GT Squiers, MA McLellan, MT Bolisetty… - Cell reports, 2018 - cell.com
Characterization of the cardiac cellulome, the network of cells that form the heart, is essential
for understanding cardiac development and normal organ function and for formulating …