Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Coumarin linked heterocyclic hybrids: a promising approach to develop multi target drugs for Alzheimer's disease
Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
[HTML][HTML] Recent advancements in the synthesis of fused thienopyridines and their therapeutic applications
R Shaw, R Tewari, M Yadav, E Pandey… - European Journal of …, 2024 - Elsevier
Fused thienopyridines represent a class of heterocyclic molecules that have garnered
increasing attention due to their unique structural features and versatile chemical properties …
increasing attention due to their unique structural features and versatile chemical properties …
Hybrid quinoline-thiosemicarbazone therapeutics as a new treatment opportunity for Alzheimer's disease‒synthesis, in vitro cholinesterase inhibitory potential and …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading
cause of dementia worldwide. The limited pharmacological approaches based on …
cause of dementia worldwide. The limited pharmacological approaches based on …
[HTML][HTML] In vitro and in silico evaluation of the antimicrobial and antioxidant activities of spiropyrazoline oxindole congeners
M Chalkha, K Chebbac, H Nour, A Nakkabi… - Arabian Journal of …, 2024 - Elsevier
The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic
field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one …
field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one …
Citronellal as a promising candidate for Alzheimer's disease treatment: A comprehensive study on in silico and in vivo anti-acetylcholine esterase activity
One of the primary therapeutic approaches for managing Alzheimer's disease (AD) involves
the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) …
the modulation of Acetylcholine esterase (AChE) activity to elevate acetylcholine (ACh) …
New thiazole and thiazole-chromene hybrids possessing morpholine units: Piperazine-mediated one-pot synthesis of potential acetylcholinesterase inhibitors
In the current study, new morpholine-linked thiazoles were prepared by the reaction of
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …
salicylaldehyde derivative, thiosemicarbazide, and α-bromoketones. To mediate the …
Exploring biological efficacy of coumarin clubbed thiazolo [3, 2–b][1, 2, 4] triazoles as efficient inhibitors of urease: A biochemical and in silico approach
Combating several pathological conditions associated with ureolytic enzyme (urease)
remains a formidable challenge because of the lack of effective and safe drug therapies. In …
remains a formidable challenge because of the lack of effective and safe drug therapies. In …
Synthesis and biological evaluation of 2-nitrocinnamaldehyde derived thiosemicarbazones as urease inhibitors
Hyperactivity of urease enzyme induces pathogenesis of peptic ulcers and gastritis. The
excess of urease can be reduced by introducing various inhibitors. The risk of high urease …
excess of urease can be reduced by introducing various inhibitors. The risk of high urease …