Antifungals

S Campoy, JL Adrio - Biochemical pharmacology, 2017 - Elsevier
The need for new antifungal agents is undeniable. Current therapeutic choices for the
treatment of invasive fungal infections are limited to three classes of drugs. Most used …

[HTML][HTML] Methods for in vitro evaluating antimicrobial activity: A review

M Balouiri, M Sadiki, SK Ibnsouda - Journal of pharmaceutical analysis, 2016 - Elsevier
In recent years, there has been a growing interest in researching and develo** new
antimicrobial agents from various sources to combat microbial resistance. Therefore, a …

Antifungal drug development: challenges, unmet clinical needs, and new approaches

T Roemer, DJ Krysan - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …

Green biosynthesis of silver nanoparticles using novel endophytic Rothia endophytica: Characterization and anticandidal activity

MA Elbahnasawy, AM Shehabeldine… - Journal of Drug Delivery …, 2021 - Elsevier
Nanotechnology has the ability to improve human health with novel tools for the treatment of
diseases. In this study, Rothia endophytica is a novel endophytic bacterial strain isolated …

Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome

MH Mirhakkak, X Chen, Y Ni, T Heinekamp… - Nature …, 2023 - nature.com
Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of
people with cystic fibrosis and is one of the most common causes of infectious-disease …

[HTML][HTML] Current screening methodologies in drug discovery for selected human diseases

OM Lage, MC Ramos, R Calisto, E Almeida… - Marine drugs, 2018 - mdpi.com
The increase of many deadly diseases like infections by multidrug-resistant bacteria implies
re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and …

Microbial cell factories based on filamentous bacteria, yeasts, and fungi

Q Ding, C Ye - Microbial Cell Factories, 2023 - Springer
Background Advanced DNA synthesis, biosensor assembly, and genetic circuit
development in synthetic biology and metabolic engineering have reinforced the application …

Recent advances in natural product discovery

Y Luo, RE Cobb, H Zhao - Current opinion in biotechnology, 2014 - Elsevier
Highlights•Natural products are discovered through top-down and bottom-up
approaches.•Diverse sampling provides diverse natural products.•Powerful analytical …

A comprehensive review on pharmacological activities of pachypodol: A bioactive compound of an aromatic medicinal plant Pogostemon cablin Benth

S Fatima, I Farzeen, A Ashraf, B Aslam, MU Ijaz… - Molecules, 2023 - mdpi.com
As is well known, plant products have been increasingly utilized in the pharmaceutical
industry in recent years. By combining conventional techniques and modern methodology …