Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide that is
attributed to gradual long‐term accumulation of both genetic and epigenetic changes. To …

Background Colorectal cancer (CRC) is often diagnosed in advanced stages. Circulating
tumour DNA (ctDNA) has been proposed as an early diagnostic biomarker. However, as a …

Colorectal carcinoma (CRC) is the third most common cancer in terms of diagnosis and the
second in terms of mortality. Recent studies have shown that various proteins, extracellular …

The birth of RNAi technology has pioneered actionability at the molecular level. Compared
to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With …

Colorectal cancer (CRC) is the third most common malignance. Although great efforts have
been made to understand the pathogenesis of CRC, the underlying mechanisms are still …

Colorectal cancer (CRC) is the third most common malignancy and ranks as the second
leading cause of cancer-related deaths worldwide. Despite the improvements in CRC …

Simple Summary The mortality of colorectal cancer is principally related to metastatic
disease at the time of diagnosis or to the growth of initially undetectable micro-metastasis …

Colorectal carcinogenesis is a multistep process involving the accumulation of genetic
alterations over time that ultimately leads to disease progression and metastasis. Binding of …

Purpose Methylated cell-free DNA in liquid biopsies are promising non-invasive biomarkers
for colorectal cancer (CRC). Optimal markers would have high sensitivity and specificity for …