Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …

Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

ZBP1 has been characterized as a critical innate immune sensor of not only viral RNA
products but also endogenous nucleic acid ligands. ZBP1 sensing of the Z‐RNA produced …

Programmed cell death is regulated by evolutionarily conserved pathways that play critical
roles in development and the immune response. A newly recognized pathway for …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was
identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the …