The molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now
well defined. The structure and function of all major fibrinolytic proteins, which include serine …

The concept of treating solid tumors by inhibiting tumor angiogenesis was first articulated
almost 30 years ago. For the next 10 years it attracted little scientific interest. This situation …

Targeted mutagenesis has allowed investigators to perform controlled experiments in
mammals and determine the contribution of individual proteins to physiologic and pathologic …

Diabetic retinopathy continues to be the leading cause of legal blindness among working-
age individuals. The earliest histological features of diabetic retinopathy include neuroretinal …

Pericellular proteases play an important role in angiogenesis and vasculogenesis. They
comprise (membrane-type) matrix metalloproteinases [(MT-) MMPs], serine proteases …

Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell
proliferation and metastatic tumor cell growth. Recently, the production of angiostatin has …

Angiostatin, a circulating inhibitor of angiogenesis, was identified by its ability to maintain
dormancy of established metastases in vivo. In vitro, angiostatin inhibits endothelial cell …

Angiogenesis is the process of sprouting and configuring new blood vessels from pre-
existing blood vessels, whereas the hemostatic system maintains the liquid flow of blood by …

Ocular neovascularization (NV) is the primary cause of blindness in a wide range of ocular
diseases, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD) …

The C‐terminal domain NC1 of mouse collagen XVIII (38 kDa) and the shorter mouse and
human endostatins (22 kDa) were prepared in recombinant form from transfected …