Nucleobase and nucleoside analogues: resistance and re-sensitisation at the level of pharmacokinetics, pharmacodynamics and metabolism
Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs
that, starting from the small field of paediatric oncology, in combination with other …
that, starting from the small field of paediatric oncology, in combination with other …
Implementing a functional precision medicine tumor board for acute myeloid leukemia
We generated ex vivo drug-response and multiomics profiling data for a prospective series
of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision …
of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision …
Clinical implications of inflammation in acute myeloid leukemia
C Récher - Frontiers in Oncology, 2021 - frontiersin.org
Recent advances in the description of the tumor microenvironment of acute myeloid
leukemia, including the comprehensive analysis of the leukemic stem cell niche and clonal …
leukemia, including the comprehensive analysis of the leukemic stem cell niche and clonal …
Carrier-free nanoplatform via evoking pyroptosis and immune response against breast cancer
L Li, H Tian, Z Zhang, N Ding, K He, S Lu… - … applied materials & …, 2022 - ACS Publications
Pyroptosis, as a novel mode of cell death, has been proven to have impressive antitumor
effects. Dying cells undergoing pyroptosis can elicit antitumor immunity by the release of …
effects. Dying cells undergoing pyroptosis can elicit antitumor immunity by the release of …
Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia
Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …
The glucocorticoid receptor associates with the cohesin loader NIPBL to promote long-range gene regulation
The cohesin complex is central to chromatin loo**, but mechanisms by which these long-
range chromatin interactions are formed and persist remain unclear. We demonstrate that …
range chromatin interactions are formed and persist remain unclear. We demonstrate that …
Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia
I Laverdière, M Boileau, AL Neumann, H Frison… - Blood cancer …, 2018 - nature.com
Therapy for acute myeloid leukemia (AML) involves intense cytotoxic treatment and yet
approximately 70% of AML are refractory to initial therapy or eventually relapse. This is at …
approximately 70% of AML are refractory to initial therapy or eventually relapse. This is at …
Inhibition of exosome release sensitizes U937 cells to PEGylated liposomal doxorubicin
Aims Acute myeloblastic leukemia (AML) is the most common type of acute leukemia in
adults. Despite numerous treatment strategies including chemotherapy and radiotherapy, a …
adults. Despite numerous treatment strategies including chemotherapy and radiotherapy, a …
Improved outcome for AML patients over the years 2000–2014
S Bertoli, S Tavitian, A Huynh, C Borel… - Blood cancer …, 2017 - nature.com
Few recent studies from registries have reported an improvement in overall survival of
younger patients with acute myeloid leukemia (AML). However, reasons for this …
younger patients with acute myeloid leukemia (AML). However, reasons for this …
Hyperleukocytosis and leukostasis in acute and chronic leukemias
Leukostasis is a life-threatening complication of high concentrations of circulating leukemic
cells, most often myeloblasts. Effective care of patients with leukostasis involves early …
cells, most often myeloblasts. Effective care of patients with leukostasis involves early …