Migration is essential for the laminar stratification and connectivity of neurons in the central
nervous system. In the retina, photoreceptors (PRs) migrate to positions according to …

Newborn neurons follow molecular cues to reach their final destination, but whether early
life experience influences lamination remains largely unexplored. As light is among the first …

Ras-specific guanine nucleotide-releasing factor 2 (RasGRF2) is a member of the guanine
nucleotide exchange factors family which is expressed in a variety of tissues and cancer …

Abstract The small GTPase Arl3 is important for the enrichment of lipidated proteins to
primary cilia, including the outer segment of photoreceptors. Human mutations in the small …

ABSTRACT Using Sos1 knockout (Sos1-KO), Sos2-KO, and Sos1/2 double-knockout
(Sos1/2-DKO) mice, we assessed the functional role of Sos1 and Sos2 in skin homeostasis …

Measuring vision in rodents is a critical step for understanding vision, improving models of
human disease, and develo** therapies. Established behavioural tests for perceptual …

Background HRASKO/NRASKO double knockout mice exhibit exceedingly high rates of
perinatal lethality due to respiratory failure caused by a significant lung maturation delay …

Hypoglycosylation of α-dystroglycan (α-DG) resulting from deficiency of protein O-
mannosyltransferase 1 (POMT1) may cause severe neuromuscular dystrophies with brain …

Fluorescent reporter lines generated in human pluripotent stem cells are a highly useful tool
to track, isolate, and analyze cell types and lineages in live cultures. Here, we generate the …

The laminated structure of the retina is fundamental for the organization of the synaptic
circuitry that translates light input into patterns of action potentials. However, the molecular …