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Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment
Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …
infectious inflammatory diseases, which continuously pose one of the most serious threats to …
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
Nanoparticle display of prefusion coronavirus spike elicits S1-focused cross-reactive antibody response against diverse coronavirus subgenera
GB Hutchinson, OM Abiona, CT Ziwawo… - Nature …, 2023 - nature.com
Multivalent antigen display is a fast-growing area of interest toward broadly protective
vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer …
vaccines. Current nanoparticle-based vaccine candidates demonstrate the ability to confer …
An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection
Zika virus (ZIKV), an arbovirus transmitted by mosquitoes, was identified as a cause of
congenital disease during a major outbreak in the Americas in 2016. Vaccine design …
congenital disease during a major outbreak in the Americas in 2016. Vaccine design …
Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants
SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized …
Potent neutralization of SARS-CoV-2 variants by RBD nanoparticle and prefusion-stabilized spike immunogens
We previously described a two-component protein nanoparticle vaccine platform that
displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when …
displays 60 copies of the SARS-CoV-2 spike protein RBD (RBD-NP). The vaccine, when …
Immunogenicity and efficacy of a novel multi-patch SARS-CoV-2/COVID-19 vaccine candidate
Introduction While there has been considerable progress in the development of vaccines
against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has …
against SARS-CoV-2, largely based on the S (spike) protein of the virus, less progress has …
Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized …
Several COVID-19 vaccine strategies utilizing new formulations for the induction of
neutralizing antibodies (nAbs) and T cell immunity are still under evaluation in preclinical …
neutralizing antibodies (nAbs) and T cell immunity are still under evaluation in preclinical …
Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
To combat future SARS-CoV-2 variants and spillovers of SARS-like betacoronaviruses
(sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting …
(sarbecoviruses) threatening global health, we designed mosaic nanoparticles presenting …
Preclinical immunogenicity and protective efficacy of a SARS-CoV-2 RBD-based vaccine produced with the thermophilic filamentous fungal expression system …
Introduction The emergency use of vaccines has been the most efficient way to control the
coronavirus disease 19 (COVID-19) pandemic. However, the emergence of severe acute …
coronavirus disease 19 (COVID-19) pandemic. However, the emergence of severe acute …