RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …

Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

Efficient targeted control of splicing is a major goal of functional genomics and therapeutic
applications. Guide (g) RNA-directed, deactivated (d) Cas CRISPR enzymes fused to …

RNA-binding proteins (RBPs) play an essential role in regulating the function of RNAs in a
cellular context, but our ability to control RBP activity in time and space is limited. Here, we …

High-throughput methodologies have enabled routine generation of RNA target sets and
sequence motifs for RNA-binding proteins (RBPs). Nevertheless, quantitative approaches …

Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of
fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to …

Insects play important roles as predators, prey, pollinators, recyclers, hosts, parasitoids, and
sources of economically important products. They can also destroy crops; wound animals; …

Tandem repeat proteins (TRPs) are widely distributed and bind to a wide variety of ligands.
DNA-binding TRPs such as zinc finger (ZNF) and transcription activator-like effector (TALE) …

Pentatricopeptide repeat (PPR) proteins bind RNA via a mechanism that facilitates the
customization of sequence specificity. However, natural PPR proteins have irregular …

RNA–protein interactions play an important role in numerous cellular processes in health
and disease. In recent years, the global RNA-bound proteome has been extensively studied …