Copper in diseases and treatments, and copper‐based anticancer strategies
Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins …
growth and development. It is important for the function of several enzymes and proteins …
Copper complexes as anticancer agents
Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …
Copper and its complexes in medicine: a biochemical approach
I Iakovidis, I Delimaris… - Molecular biology …, 2011 - Wiley Online Library
The fundamental role of copper and the recognition of its complexes as important bioactive
compounds in vitro and in vivo aroused an ever‐increasing interest in these agents as …
compounds in vitro and in vivo aroused an ever‐increasing interest in these agents as …
Coordination compounds in cancer: Past, present and perspectives
Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …
Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents
Oxindoles are endogenous compounds found in mammalian body fluids and tissues.
Particularly, isatin (1H-indole-2, 3-dione) and its derivatives have shown a variety of …
Particularly, isatin (1H-indole-2, 3-dione) and its derivatives have shown a variety of …
In vitro antitumour activity of water soluble Cu (I), Ag (I) and Au (I) complexes supported by hydrophilic alkyl phosphine ligands
Hydrophilic, monocationic [M (L) 4] PF6 complexes (M= Cu or Ag; L: thp= tris
(hydroxymethyl) phosphine, L: PTA= 1, 3, 5-triaza-7-phosphaadamantane, L: thpp= tris …
(hydroxymethyl) phosphine, L: PTA= 1, 3, 5-triaza-7-phosphaadamantane, L: thpp= tris …
Synthesis and biological activity of ester-and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes
M Pellei, V Gandin, M Marinelli, C Marzano… - Inorganic …, 2012 - ACS Publications
N-Heterocyclic carbene (NHC) ligand precursors, namely, HImACl [1, 3-bis (2-ethoxy-2-
oxoethyl)-1 H-imidazol-3-ium chloride] and HImBCl {1, 3-bis [2-(diethylamino)-2-oxoethyl]-1 …
oxoethyl)-1 H-imidazol-3-ium chloride] and HImBCl {1, 3-bis [2-(diethylamino)-2-oxoethyl]-1 …
In vitro antitumor activity of the water soluble copper (I) complexes bearing the tris (hydroxymethyl) phosphine ligand
C Marzano, V Gandin, M Pellei, D Colavito… - Journal of medicinal …, 2008 - ACS Publications
Monocationic hydrophilic complexes [Cu (thp) 4]+ 3 and [Cu (bhpe) 2]+ 4 were synthesized
by ligand exchange reactions starting from the labile [Cu (CH3CN) 4][PF6] precursor in the …
by ligand exchange reactions starting from the labile [Cu (CH3CN) 4][PF6] precursor in the …
Heteroleptic copper (I) complexes of “scorpionate” bis-pyrazolyl carboxylate ligand with auxiliary phosphine as potential anticancer agents: An insight into cytotoxic …
New copper (I) complexes [CuCl (PPh3)(L)](1: L= LA= 4-carboxyphenyl) bis (3, 5-
dimethylpyrazolyl) methane;(2: L= LB= 3-carboxyphenyl) bis (3, 5-dimethylpyrazolyl) …
dimethylpyrazolyl) methane;(2: L= LB= 3-carboxyphenyl) bis (3, 5-dimethylpyrazolyl) …
Novel mixed-ligand copper (I) complexes: role of diimine ligands on cytotoxicity and genotoxicity
Novel tetrahedral copper (I) mixed-ligand complexes of the type [Cu (X)(N∩ N)(PCN)], 3–10,
where X= Cl or Br, N∩ N= 2, 2′-bipyridine (bipy), 1, 10-phenanthroline (phen), 5, 6 …
where X= Cl or Br, N∩ N= 2, 2′-bipyridine (bipy), 1, 10-phenanthroline (phen), 5, 6 …