With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

We provide a critical assessment of explicit‐solvent atomistic molecular dynamics (MD)
simulations of RNA and protein/RNA complexes, written primarily for non‐specialists with an …

The hammerhead ribozyme is a self-cleaving RNA broadly dispersed across all kingdoms of
life. Although it was the first of the small, nucleolytic ribozymes discovered, the mechanism …

Various self-cleaving ribozymes appearing in nature catalyze the sequence-specific
intramolecular cleavage of RNA and can be engineered to catalyze cleavage of appropriate …

The hepatitis delta virus (HDV) ribozyme catalyzes a self-cleavage reaction using a
combination of nucleobase and metal ion catalysis. Both divalent and monovalent ions can …

The TS ribozyme (originally called “twister sister”) is a catalytic RNA. We present a crystal
structure of the ribozyme in a pre-reactive conformation. Two co-axial helical stacks are …

Recently, a few Na+-specific RNA-cleaving DNAzymes were reported, where nucleobases
are likely to play critical roles in catalysis. The NaA43 and NaH1 DNAzymes share the same …

The hepatitis delta virus (HDV) ribozyme self-cleaves in the presence of a wide range of
monovalent and divalent ions. Prior theoretical studies provided evidence that self-cleavage …