The immune system has crucial roles in cancer development and treatment. Whereas
adaptive immunity can prevent or constrain cancer through immunosurveillance, innate …

The tumour microenvironment is the primary location in which tumour cells and the host
immune system interact. Different immune cell subsets are recruited into the tumour …

Glioblastoma (GBM) is an aggressive primary brain cancer, with a 5 year survival of∼ 5%.
Challenges that hamper GBM therapeutic efficacy include (i) tumor heterogeneity,(ii) …

Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Among the most extensively researched processes in the development and treatment of
cancer is inflammatory condition. Although acute inflammation is essential for the wound …

Chimeric antigen receptor (CAR)-T cell therapy has achieved successful outcomes against
hematological malignancies and provided a new impetus for treating solid tumors. However …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Chemokines mediate numerous physiological and pathological processes related primarily
to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived …

Classical chemotherapeutic anti-cancer treatments induce cell death through DNA damage
by taking advantage of the proliferative behaviour of cancer cells. The more recent approach …

Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the
functional contributions of these cells to tumorigenesis are poorly understood. Using a …