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Redefining phenotypes to advance psychiatric genetics: Implications from hierarchical taxonomy of psychopathology.
Genetic discovery in psychiatry and clinical psychology is hindered by suboptimal
phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven …
phenotypic definitions. We argue that the hierarchical, dimensional, and data-driven …
Research Review: A guide to computing and implementing polygenic scores in developmental research
The increasing availability of genotype data in longitudinal population‐and family‐based
samples provides opportunities for using polygenic scores (PGS) to study developmental …
samples provides opportunities for using polygenic scores (PGS) to study developmental …
Evaluation of polygenic prediction methodology within a reference-standardized framework
The predictive utility of polygenic scores is increasing, and many polygenic scoring methods
are available, but it is unclear which method performs best. This study evaluates the …
are available, but it is unclear which method performs best. This study evaluates the …
Genetic associations between non-cognitive skills and academic achievement over development
Non-cognitive skills, such as motivation and self-regulation, are partly heritable and predict
academic achievement beyond cognitive skills. However, how the relationship between non …
academic achievement beyond cognitive skills. However, how the relationship between non …
Predicting educational achievement from genomic measures and socioeconomic status
The two best predictors of children's educational achievement available from birth are
parents' socioeconomic status (SES) and, recently, children's inherited DNA differences that …
parents' socioeconomic status (SES) and, recently, children's inherited DNA differences that …
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
Prediction from early childhood vocabulary to academic achievement at the end of compulsory schooling in Denmark
Prediction from early development to later achievement has the potential to improve clinical
and educational service delivery as well as to inform developmental theory. In this …
and educational service delivery as well as to inform developmental theory. In this …
Twins Early Development Study (TEDS): A genetically sensitive investigation of mental health outcomes in the mid‐twenties
Abstract The Twins Early Development Study (TEDS) is a longitudinal study following a
cohort of twins born 1994–1996 in England and Wales. Of the 13,759 families who originally …
cohort of twins born 1994–1996 in England and Wales. Of the 13,759 families who originally …
Reciprocal effects between negative parenting and children's callous-unemotional traits from mid to late childhood
Objective: The role of negative parenting in the development of callous-unemotional (CU)
traits remains unclear. Both negative parenting and CU traits are influenced by genetic and …
traits remains unclear. Both negative parenting and CU traits are influenced by genetic and …
Estimating effects of parents' cognitive and non-cognitive skills on offspring education using polygenic scores
Understanding how parents' cognitive and non-cognitive skills influence offspring education
is essential for educational, family and economic policy. We use genetics (GWAS-by …
is essential for educational, family and economic policy. We use genetics (GWAS-by …