Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models

HF Wu, W Yu, K Saito-Diaz, CW Huang, J Carey… - Nature …, 2022 - nature.com
Familial dysautonomia (FD), a rare neurodevelopmental and neurodegenerative disorder
affects the sympathetic and sensory nervous system. Although almost all patients harbor a …

神经嵴细胞和神经嵴病及其致病机制的研究进展

蒋卓远, 查艳, 石小峰, 张永彪 - 遗传, 2022 - chinagene.cn
神经嵴细胞(neural crest cells, NCCs) 是一类脊椎动物特有的可迁移的多能干细胞,
其可分化为软骨细胞, 神经元和黑色素细胞等多种类型细胞. NCCs 的形成, 迁移和分化受到严格 …

Establishing the zebrafish as a model to study the genetics of nociception

EDSCEV Clemente - 2022 - discovery.ucl.ac.uk
Pain is crucial for survival, and the ability to detect potentially harmful stimuli and respond
accordingly is evolutionarily conserved. However, pain can also be undesirable in several …

Norepinephrine transporter defects lead to sympathetic hyperactivity in stem cell and mouse models of Familial Dysautonomia

HF Wu, W Yu, J Carey, F Lefcort, H Liu, N Zeltner - 2021 - researchsquare.com
Familial dysautonomia (FD) is a rare neurodevelopmental and neurodegenerative disorder
that affects the sympathetic nervous system. Patients harbor a mutation in ELP1 yet, how …