The mechanisms of leukocyte recruitment have been studied extensively in vitro and have
shed light on the basic molecular structure-function relationship of adhesion and signaling …

Much information has been obtained regarding how white cells are recruited in the
microcirculation to sites of inflammation. In this review we summarize the leukocyte …

Bloodstream infection is a hallmark of sepsis, a medically emergent condition requiring rapid
treatment. However, up-regulation of host defense proteins through Toll-like receptors …

The response to tissue injury involves the coordination of inflammatory and repair
processes. IL-6 expression correlates with the onset and severity of acute kidney injury …

We have used intravital microscopy to study physiologically perfused microvessels in murine
bone marrow (BM). BM sinusoids and venules, but not adjacent bone vessels, supported …

Platelet microparticles (PMPs) are released from activated platelets and express functional
adhesion receptors, including P-selectin, on their surface. PMP concentrations are elevated …

Lymphocyte recruitment into the brain is a critical event in the pathogenesis of multiple
sclerosis and experimental autoimmune encephalomyelitis. We developed a novel intravital …

Microbial pathogens subvert host adhesion molecules to disseminate or to enter host cells to
promote their own survival. One such subversion is the cytoadherence of Plasmodium …

In order to extravasate the bloodstream at specific sites of inflammation or antigen
presentation, circulating leukocytes must rapidly translate specific adhesive and stimulatory …

Experimental autoimmune encephalomyelitis (EAE) is mediated by inflammatory cells
recruited from the circulation to the CNS. We used intravital microscopy to investigate the …