DNA double-strand breaks (DSBs) are among the most serious forms of DNA damage. In
humans, DSBs are repaired mainly by non-homologous end joining (NHEJ) and …

The integration of structural variations (SVs) in statistical genetics provides an opportunity to
understand the genetic factors influencing complex human traits and disease. Recent …

Mobile element insertions (MEIs) are a major class of structural variants (SVs) and have
been linked to many human genetic disorders, including hemophilia, neurofibromatosis, and …

Thousands of unfixed transposable element (TE) insertions segregate in the human
population, but little is known about their impact on genome function. Recently, a few studies …

Abstract Background Endogenous retroviruses (ERVs) are the remnants of retroviral
infections which can elicit prolonged genomic and immunological stress on their host …

Ongoing retrotransposition of Alu, LINE-1, and SINE–VNTR–Alu elements generates
diversity and variation among human populations. Previous analyses investigating the …

Transposable element (TE) mobilization is a significant source of genomic variation and has
been associated with various human diseases. The exponential growth of population‐scale …

Transposable element (TE) insertions are a major source of structural variation in the human
genome. Due to the repetitive nature and biological importance of TEs, many bioinformatic …

Genetic variation contributes significantly to Parkinson's disease (PD) risk, onset, and
progression. However, most of the common genetic variation that contributes to PD is still …

Transposable elements (TEs) are an important cause of evolutionary change and functional
diversity, yet they are routinely discarded in the first steps of many analyses. In this chapter …