[HTML][HTML] Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy

VL Breton, MS Aquilino, S Repudi, A Saleem… - Neurobiology of …, 2021 - Elsevier
Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are
associated with severe and fatal drug-resistant pediatric epileptic encephalopathy. Epileptic …

H-and m-channel overexpression promotes seizure-like events by impairing the ability of inhibitory neurons to process correlated inputs

S Rich, TA Valiante, J Lefebvre - bioRxiv, 2024 - biorxiv.org
Channelopathies affecting h-and m-channels present a paradox in epilepsy research: while
both over-and underexpression of these channels can be epileptogenic, channel …

Glutamate's Secret Interictal Life

ER Cullen, MC Weston - Epilepsy Currents, 2021 - journals.sagepub.com
The transition between seizure and non-seizure states in neocortical epileptic networks is
governed by distinct underlying dynamical processes. Based on the gamma distribution of …

[PDF][PDF] RESEARCH THESIS PROJECT

M Douloudi - pergamos.lib.uoa.gr
The incidence of drug-resistant seizures and epilepsy is considerably high in children, but
the underlying etiology for their refractoriness to antiepileptic treatment remains elusive. As …