Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating
children and adults with uncomplicated malaria or as chemoprophylaxis for preventing …

Polymyxin B and colistin were examined for their ability to inhibit the type II NADH-quinone
oxidoreductases (NDH-2) of three species of Gram-negative bacteria. Polymyxin B and …

The goal for develo** new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …

The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with
proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by …

The threat of widespread drug resistance to frontline antimalarials has renewed the urgency
for identifying inexpensive chemotherapeutic compounds that are effective against …

Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Quinolones are a type of bicyclic privileged building block with immense therapeutic
potential. They are known for their crucial role in modulating numerous diseases conditions …

The mitochondrial electron transport chain (mETC) and F1Fo-ATP synthase are of central
importance for energy and metabolism in eukaryotic cells. The Apicomplexa, important …