Chitosan-based drug delivery systems: from synthesis strategy to osteomyelitis treatment–a review

F Tao, S Ma, H Tao, L **, Y Luo, J Zheng, W **ang… - Carbohydrate …, 2021 - Elsevier
Osteomyelitis is a complex disease in orthopedics mainly caused by bacterial pathogens
invading bone or bone marrow. The treatment of osteomyelitis is highly difficult and it is a …

Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis

BD Gimza, JE Cassat - Frontiers in immunology, 2021 - frontiersin.org
Staphylococcus aureus is a highly successful Gram-positive pathogen capable of causing
both superficial and invasive, life-threatening diseases. Of the invasive disease …

Recapitulating antioxidant and antibacterial compounds into a package for tissue regeneration: dual function materials with synergistic effect

M Shao, A Bigham, S Yousefiasl, CKY Yiu, YR Girish… - Small, 2023 - Wiley Online Library
Oxidative damage and infection can prevent or delay tissue repair. Moreover, infection
reinforces reactive oxygen species (ROS) formation, which makes the wound's condition …

Iodine Immobilized Metal–Organic Framework for NIR‐Triggered Antibacterial Therapy on Orthopedic Implants

W Teng, Z Zhang, Y Wang, Y Ye, E Yinwang, A Liu… - Small, 2021 - Wiley Online Library
Iodine has been known as an effective disinfectant with broad‐spectrum antimicrobial
potency yet without drug resistance risk when used in clinic. However, the exploration of …

Interface Polarization Strengthened Microwave Catalysis of MoS2/FeS/Rhein for the Therapy of Bacteria‐Infected Osteomyelitis

L **, X Liu, Y Zheng, Z Li, Y Zhang… - Advanced Functional …, 2022 - Wiley Online Library
Abstract Staphylococcus aureus (S. aureus)‐induced osteomyelitis is fatal to patients, even
leading to death without timely debridement processing, which is difficult to be treated by …

A multifunctional scaffold for bone infection treatment by delivery of microRNA therapeutics combined with antimicrobial nanoparticles

JM Sadowska, RN Power, KJ Genoud… - Advanced …, 2024 - Wiley Online Library
Treating bone infections and ensuring bone repair is one of the greatest global challenges
of modern orthopedics, made complex by antimicrobial resistance (AMR) risks due to long …

[HTML][HTML] Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair

S Wang, W He, H Wang, D Liu, M Wang, H Yang… - Bioactive Materials, 2023 - Elsevier
Infected bone fractures remain a major clinical challenge for orthopedic surgeons. From a
tissue regeneration perspective, biomaterial scaffolds with antibacterial and osteoinductive …

Magnetic Composite Rapidly Treats Staphylococcus aureus‐Infected Osteomyelitis through Microwave Strengthened Thermal Effects and Reactive Oxygen Species

L **, Y Zheng, X Liu, Y Zhang, Z Li, Y Liang, S Zhu… - Small, 2022 - Wiley Online Library
It is difficult to effectively treat bacterial osteomyelitis using photothermal therapy or
photodynamic therapy due to poor penetration of light. Here, a microwave (MW)‐excited …

Enhancing Microwave Dynamic Effects via Surface States of Ultrasmall 2D MOF Triggered by Interface Confinement for Antibiotics‐Free Therapy

Y Qiao, S Wu, Y Zheng, C Wang, Z Li… - Advanced …, 2023 - Wiley Online Library
Microwave (MV)‐trigged dynamic therapy based on MV‐responsive materials is promising
for treating deep infection diseases that cannot be effectively treated by antibiotics, like life …

[HTML][HTML] In situ sprayed hydrogels containing resiquimod-loaded liposomes reduce chronic osteomyelitis recurrence by intracellular bacteria clearance

L Tian, Z Tan, Y Yang, S Liu, Q Yang, Y Tu, J Chen… - Acta Biomaterialia, 2023 - Elsevier
At present, surgical debridement and systematic administration of antibiotics represent the
mainstay of treatment for chronic osteomyelitis. However, it is now understood that …