Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …

Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Myocardial ischemia–reperfusion (I/R) injury most commonly occurs in coronary artery
disease when prompt reperfusion is used to salvage the ischemic myocardium …