The insulin secretory response by pancreatic β-cells to an acute “square wave” stimulation
by glucose is characterized by a first phase that occurs promptly after exposure to glucose …

Secretion of the peptide hormone insulin from pancreatic β cells constitutes an important
step in the regulation of body homeostasis. Insulin is stored in large dense core vesicles and …

Summary α-synuclein and cysteine-string protein-α (CSPα) are abundant synaptic vesicle
proteins independently linked to neurodegeneration. Dominantly inherited mutations in α …

Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-
J domain characteristic of Hsp40 chaperones—is thought to regulate Ca 2+ channels and/or …

The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …

The dynamics of exocytosis are diverse and have been optimized for the functions of
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …

Molecular chaperones are best recognized for their roles in de novo protein folding and the
cellular response to stress. However, many molecular chaperones, and in particular the …

Insulin secretory granules (ISGs) are cytoplasmic organelles of pancreatic β-cells. They are
responsible for the storage and secretion of insulin. To date, only about 30 different proteins …

Cysteine‐string protein (Csp) is a major synaptic vesicle and secretory granule protein first
discovered in Drosophila and Torpedo. Csps were subsequently identified from Xenopus …

Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 family of co-chaperones that
localises to neuronal synaptic vesicles. Its name derives from the possession of a string of …