Single-particle cryogenic electron-microscopy (cryo-EM) has emerged as a powerful
technique for the structural characterisation of membrane proteins, especially for targets …

Structure-based drug design (SBDD) has gained popularity owing to its ability to develop
more potent drugs compared to conventional drug-discovery methods. The success of …

RNAs are critical for complex cellular functions, characterized by their structural versatility
and ability to undergo conformational transitions in response to cellular cues. The elusive …

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by providing high-
resolution insights into biological macromolecules. Here, we present sub-3 Å resolution …

Advancements in cryo-electron microscopy (cryoEM) techniques over the past decade have
allowed structural biologists to routinely resolve macromolecular protein complexes to near …

Ever since the resolution revolution in 2013, cryo-electron microscopy (cryo-EM) has
become a powerful methodology in structural biology that is especially suited to study the …

In cryogenic electron microscopy (cryo-EM), purified macromolecules are typically applied to
a grid bearing a holey carbon foil, blotted to remove excess liquid and rapidly frozen in a …

CryoEM multi-grid screening is often a tedious process that demands hours of attention.
Here, this protocol shows how to set up standard Leginon collection and Smart Leginon …

Продемонстрирован пример успешной модернизации аналитического
просвечивающего электронного микроскопа JEOL JEM-2100 до криоэлектронного …

Setting up a new cryo-EM facility to obtain high-resolution protein structures is becoming
increasingly common in both academic scientific research and industry. Here we describe …