Ionized calcium (Ca2+) is the most versatile cellular messenger. All cells use Ca2+ signals
to regulate their activities in response to extrinsic and intrinsic stimuli. Alterations in cellular …

Cellular homeostasis is essential for healthy functioning of cells and tissues as well as
proper organ development and maintenance. A disruption in cellular homeostasis triggers …

ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel crucial
for life. Whereas ORAI1 activation by Ca2+-sensing STIM proteins is known, still obscure is …

In this review article, we discuss the different gene products and translational variants of
ORAI proteins and their contribution to the makeup of different native calcium-conducting …

Asthma is one of the main non-communicable chronic diseases and affects a huge portion of
the population. It is a multifactorial disease, classified into several phenotypes, being the …

Endoplasmic reticulum in oocytes The storage and release of calcium ions (Ca2+) in oocyte
maturation and fertilization are particularly noteworthy features of the endoplasmic reticulum …

Abstract Inositol 1, 4, 5-trisphosphate receptors (IP 3 R) are the most widely expressed
intracellular Ca 2+ release channels. Their activation by IP 3 and Ca 2+ allows Ca 2+ to …