Fueled by developments in computational neuroscience, there has been increasing interest
in the underlying neurocomputational mechanisms of psychosis. One successful approach …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Objectives: This guideline provides recommendations for the clinical management of
schizophrenia and related disorders for health professionals working in Australia and New …

Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …

The third edition of the hugely successful Handbook of Child and Adolescent Clinical
Psychology incorporates important advances in the field to provide a reliable and accessible …

Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …

Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Multiple lines of evidence support the pathogenic role of neuroinflammation in psychiatric
illness. While systemic autoimmune diseases are well-documented causes of …

Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …

The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …