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Marine natural products
Covering: 2008. Previous review: Nat. Prod. Rep., 2009, 26, 170This review covers the
literature published in 2008 for marine natural products, with 829 citations (613 for the …
literature published in 2008 for marine natural products, with 829 citations (613 for the …
Discorhabdins and pyrroloiminoquinone-related alkaloids
Alkaloids, such as lamellarins1 and manzamines, 2 with complex structures and promising
biological activities produced by marine plants, invertebrates and microbes have greatly …
biological activities produced by marine plants, invertebrates and microbes have greatly …
Determination of absolute configuration of natural products: theoretical calculation of electronic circular dichroism as a tool
Determination of absolute configuration (AC) is one of the most challenging features in the
structure elucidation of chiral natural products, especially those with complex structures …
structure elucidation of chiral natural products, especially those with complex structures …
Unified Divergent Total Synthesis of Discorhabdin B, H, K, and Aleutianamine via the Late-Stage Oxidative N,S-Acetal Formation
M Shimomura, K Ide, J Sakata… - Journal of the American …, 2023 - ACS Publications
This study achieved the total syntheses of (+)-discorhabdin B,(−)-discorhabdin H,(+)-
discorhabdin K, and (−)-aleutianamine. A phenethylamine fragment bearing ao-pivaloylthio …
discorhabdin K, and (−)-aleutianamine. A phenethylamine fragment bearing ao-pivaloylthio …
Total Synthesis of (+)‐Discorhabdin V
The discorhabdin natural products are a large subset of pyrroloiminoquinone alkaloids with
a myriad of biological activities. Despite garnering much synthetic attention, few members …
a myriad of biological activities. Despite garnering much synthetic attention, few members …
Occurrence of halogenated alkaloids
GW Gribble - The Alkaloids: Chemistry and Biology, 2012 - Elsevier
The number of known natural organohalogen compounds of all types has grown from 30 in
1968 to> 5000 today. About 25% of halogenated natural products are alkaloids, mostly …
1968 to> 5000 today. About 25% of halogenated natural products are alkaloids, mostly …
Absolute structural elucidation of natural products—A focus on quantum‐mechanical calculations of solid‐state CD spectra
In this review article we examine state‐of‐the‐art techniques for the structural elucidation of
organic compounds isolated from natural sources. In particular, we focus on the …
organic compounds isolated from natural sources. In particular, we focus on the …
[HTML][HTML] Current perspectives on pyrroloiminoquinones: distribution, biosynthesis and drug discovery potential
Pyrroloiminoquinones are a group of cytotoxic alkaloids most commonly isolated from
marine sponges. Structurally, they are based on a tricyclic pyrrolo [4, 3, 2-de] quinoline core …
marine sponges. Structurally, they are based on a tricyclic pyrrolo [4, 3, 2-de] quinoline core …
Natural products from sponges
BN Han, LL Hong, BB Gu, YT Sun, J Wang… - … Microbiomes of Coral …, 2019 - Springer
The sponge is one of the oldest multicellular invertebrates in the world. Marine sponges
represent one of the extant metazoans of 700–800 million years. They are classified in four …
represent one of the extant metazoans of 700–800 million years. They are classified in four …
[HTML][HTML] An investigation of structure–activity relationships and cell death mechanisms of the marine alkaloids discorhabdins in Merkel Cell Carcinoma Cells
A library of naturally occurring and semi-synthetic discorhabdins was assessed for their
effects on Merkel cell carcinoma (MCC) cell viability. The set included five new natural …
effects on Merkel cell carcinoma (MCC) cell viability. The set included five new natural …