Long-term potentiation (LTP) and long-term depression (LTD) comprise the principal cellular
mechanisms that fulfill established criteria for the physiological correlates of learning and …

Memory allows organisms to predict future events based on prior experiences. This requires
encoded information to persist once important predictors are extracted, while also being …

Dopamine (DA) plays an essential role in the enablement of cognition. It adds color to
experience-dependent information storage, conferring salience to the memories that result …

Autism spectrum disorder (ASD) depends on a clinical interview with no biomarkers to aid
diagnosis. The current investigation interrogated single-nucleotide polymorphisms (SNPs) of …

Storage and processing of information at the synaptic level is enabled by the ability of
synapses to persistently alter their efficacy. This phenomenon, known as synaptic plasticity …

Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising
agents under development for the treatment of psychiatric disorders. The research in this …

Although synaptic plasticity is believed to comprise the cellular substrate for learning and
memory, limited direct evidence exists that hippocampus-dependent learning actually …

Converging lines of evidence strongly support a role for sleep in brain plasticity. An elegant
idea that may explain how sleep accomplishes this role is the “synaptic homeostasis …

Exposure to a novel environment enhances the extinction of contextual fear. This has been
explained by tagging of the hippocampal synapses used in extinction, followed by capture of …

The noradrenergic system, driven by locus coeruleus (LC) activation, plays a key role in the
regulating and directing of changes in hippocampal synaptic efficacy. The LC releases …