Abstract The Hedgehog (Hh) signaling pathway coordinates cell–cell communication in
development and regeneration. Defects in this pathway underlie diseases ranging from birth …

The transverse asymmetry (sidedness) of phospholipids in plasma membrane bilayers is
well characterized, distinctive, actively maintained and functionally important. In contrast …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is
liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

Cholesterol is a major structural component of the plasma membrane (PM). The majority of
PM cholesterol forms complexes with other PM lipids, making it inaccessible for intracellular …

Previously we proposed that transmission of the hedgehog signal across the plasma
membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al …

Cholesterol is essential for cell physiology. Transport of the “accessible” pool of cholesterol
from the plasma membrane (PM) to the endoplasmic reticulum (ER) by ER‐localized …

Cholesterol transport between intracellular compartments proceeds by both energy‐and non‐
energy‐dependent processes. Energy‐dependent vesicular traffic partly contributes to …

Most cholesterol in mammalian cells is stored in the plasma membrane (PM). Cholesterol
transport from the PM to low-sterol regulatory regions of the endoplasmic reticulum (ER) …