The genetics of type 2 diabetes: what have we learned from GWAS?
LK Billings, JC Florez - Annals of the New York Academy of …, 2010 - Wiley Online Library
Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …
Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease
M Foster, S Samman - Nutrients, 2012 - mdpi.com
In atherosclerosis and diabetes mellitus, the concomitant presence of low-grade systemic
inflammation and mild zinc deficiency highlights a role for zinc nutrition in the management …
inflammation and mild zinc deficiency highlights a role for zinc nutrition in the management …
Zinc and insulin in pancreatic beta-cells
YV Li - Endocrine, 2014 - Springer
Abstract Zinc (Zn 2+) is an essential element crucial for growth and development, and also
plays a role in cell signaling for cellular processes like cell division and apoptosis. In the …
plays a role in cell signaling for cellular processes like cell division and apoptosis. In the …
Zinc transporter 8 (ZnT8) and β cell function
HW Davidson, JM Wenzlau, RM O'Brien - Trends in Endocrinology & …, 2014 - cell.com
Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc
concentration is in insulin secretory granules, from which it is cosecreted with the hormone …
concentration is in insulin secretory granules, from which it is cosecreted with the hormone …
Zinc, a regulator of islet function and glucose homeostasis
N Wijesekara, F Chimienti… - Diabetes, Obesity and …, 2009 - Wiley Online Library
It is well known that zinc is required in pancreatic β‐cells in the process of insulin
biosynthesis and the maturation of insulin secretory granules. In fact, the zinc level in …
biosynthesis and the maturation of insulin secretory granules. In fact, the zinc level in …
Islet autoantigens: structure, function, localization, and regulation
Islet autoantigens associated with autoimmune type 1 diabetes (T1D) are expressed in
pancreatic β cells, although many show wider patterns of expression in the neuroendocrine …
pancreatic β cells, although many show wider patterns of expression in the neuroendocrine …
The association between serum zinc level and overweight/obesity: a meta-analysis
K Gu, W **ang, Y Zhang, K Sun, X Jiang - European journal of nutrition, 2019 - Springer
Purpose The association between serum zinc level and overweight/obesity remains
controversial. Hence, we performed a meta-analysis to summarize the relationships …
controversial. Hence, we performed a meta-analysis to summarize the relationships …
Zinc, zinc transporters and diabetes
J Rungby - Diabetologia, 2010 - Springer
The role of zinc in islet function has recently achieved new attention as a consequence of
the identification of zinc transporter 8 (ZNT8) in islets, and the association of mutations in the …
the identification of zinc transporter 8 (ZNT8) in islets, and the association of mutations in the …
Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …
organs, including eyes, kidneys, and cardiovascular system. According to the World Health …
1, 25-Dihydroxyvitamin D3 upregulates leptin expression in mouse adipose tissue
J Kong, Y Chen, G Zhu, Q Zhao… - Journal of …, 2013 - joe.bioscientifica.com
The adult female pituitary has significantly more lactotrophs than that of the male, while the
later has a higher percent of somatotrophs. It is clear that GH and prolactin (PRL) gene …
later has a higher percent of somatotrophs. It is clear that GH and prolactin (PRL) gene …