Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Conspectus Nanozymes, nanomaterials with enzyme-like activities with high structural
stability, adjustable catalytic activity, functional diversity, recyclability, and feasibility in large …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Naturally occurring enzymes can be a source of unnatural reactivity that can be molded by
directed evolution to generate efficient biocatalysts with valuable activities. Owing to the lack …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

Cytochrome P450s (CYPs) are the largest enzyme family involved in NADPH-and/or O2-
dependent hydroxylation reactions across all the domains of life. In plants and animals …

The proportion of approved chiral drugs and drug candidates under medical studies has
surged dramatically over the past two decades. As a consequence, the efficient synthesis of …