Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

The major facilitator superfamily (MFS) is the largest known superfamily of secondary active
transporters. MFS transporters are responsible for transporting a broad spectrum of …

Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Metabolic programming in the tumor microenvironment (TME) alters tumor immunity and
immunotherapeutic response in tumor-bearing mice and patients with cancer. Here, we …

Taurine is used to bolster immunity, but its effects on antitumor immunity are unclear. Here,
we report that cancer-related taurine consumption causes T cell exhaustion and tumor …

Chemical modulation of proteins enables a mechanistic understanding of biology and
represents the foundation of most therapeutics. However, despite decades of research, 80 …

The upper gastrointestinal tract, consisting of the esophagus, stomach, and duodenum,
controls food transport, digestion, nutrient uptake, and hormone production. By single-cell …

This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

Metabolism has historically been studied at the levels of whole cells, whole tissues and
whole organisms. As a result, our understanding of how compartmentalization—the spatial …

Analyses of publicly available structural data reveal interesting insights into the impact of the
three‐dimensional (3D) structures of protein targets important for discovery of new drugs …