Algorithmic fairness in artificial intelligence for medicine and healthcare

RJ Chen, JJ Wang, DFK Williamson, TY Chen… - Nature biomedical …, 2023 - nature.com
In healthcare, the development and deployment of insufficiently fair systems of artificial
intelligence (AI) can undermine the delivery of equitable care. Assessments of AI models …

Human-in-the-loop machine learning: a state of the art

E Mosqueira-Rey, E Hernández-Pereira… - Artificial Intelligence …, 2023 - Springer
Researchers are defining new types of interactions between humans and machine learning
algorithms generically called human-in-the-loop machine learning. Depending on who is in …

Scaling vision transformers to gigapixel images via hierarchical self-supervised learning

RJ Chen, C Chen, Y Li, TY Chen… - Proceedings of the …, 2022 - openaccess.thecvf.com
Abstract Vision Transformers (ViTs) and their multi-scale and hierarchical variations have
been successful at capturing image representations but their use has been generally …

Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance

Y Chu, E Dai, Y Li, G Han, G Pei, DR Ingram… - Nature medicine, 2023 - nature.com
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …

Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

A Gavish, M Tyler, AC Greenwald, R Hoefflin, D Simkin… - Nature, 2023 - nature.com
Each tumour contains diverse cellular states that underlie intratumour heterogeneity (ITH), a
central challenge of cancer therapeutics. Dozens of recent studies have begun to describe …

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

Artificial intelligence: A powerful paradigm for scientific research

Y Xu, X Liu, X Cao, C Huang, E Liu, S Qian, X Liu… - The Innovation, 2021 - cell.com
Artificial intelligence (AI) coupled with promising machine learning (ML) techniques well
known from computer science is broadly affecting many aspects of various fields including …

A novel cuproptosis-related prognostic gene signature and validation of differential expression in clear cell renal cell carcinoma

Z Bian, R Fan, L **e - Genes, 2022 - mdpi.com
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cell
carcinoma, which is characterized by metabolic reprogramming. Cuproptosis, a novel form …

Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer

KM Boehm, EA Aherne, L Ellenson, I Nikolovski… - Nature cancer, 2022 - nature.com
Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response
to treatment. Known prognostic factors for this disease include homologous recombination …

Structure-based classification predicts drug response in EGFR-mutant NSCLC

JP Robichaux, X Le, RSK Vijayan, JK Hicks, S Heeke… - Nature, 2021 - nature.com
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are
established driver mutations in non-small cell lung cancer (NSCLC),–. Targeted therapies …