Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Mitochondrial fission is a highly regulated process that, when disrupted, can alter
metabolism, proliferation and apoptosis,–. Dysregulation has been linked to …

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

Dopamine (DA) plays a critical role in the brain, and the ability to directly measure
dopaminergic activity is essential for understanding its physiological functions. We therefore …

Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

High-speed, large-scale three-dimensional (3D) imaging of neuronal activity poses a major
challenge in neuroscience. Here we demonstrate simultaneous functional imaging of …

Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic
necrosis and dampens inflammation. Defective efferocytosis drives important diseases …