Although the genetic basis of many kidney diseases is being rapidly elucidated, their
experimental study remains problematic owing to the lack of suitable models. The fruitfly …

The circulatory system of Drosophila melanogaster represents an easily amenable genetic
model whose analysis at different levels, ie, from single molecules up to functional anatomy …

Albuminuria affects millions of people, and is an independent risk factor for kidney failure,
cardiovascular morbidity and death. The key cell that prevents albuminuria is the terminally …

Preventing aberrant immune responses against the microbiota is essential for the health of
the host. Microbiota-shed pathogen-associated molecular patterns translocate from the gut …

Podocyte injury is the inciting event in primary glomerulopathies, such as minimal change
disease and primary FSGS, and glucocorticoids remain the initial and often, the primary …

This review is dedicated to the memory of Professor Sir Vincent B. Wigglesworth (VW) in
recognition of his many pioneering contributions to insect physiology which, even today …

Both mTOR signaling and autophagy are important modulators of podocyte homeostasis,
regeneration, and aging and have been implicated in glomerular diseases. However, the …

Biological and biomedical research using Drosophila melanogaster as a model organism
has gained recognition through several Nobel prizes within the last 100 years. Drosophila …

Glomerular disorders are a major cause of end-stage renal disease and effective therapies
are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system …

Among the annelids, earthworms are renowned for their phenomenal ability to regenerate
the lost segments. The adult earthworm Eudrilus eugeniae contains 120 segments and the …