Stroke is one of the leading causes of death and long-term disability worldwide. More than
80% of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question …

Intercellular signaling and component conduction are essential for multicellular organisms'
homeostasis, and mitochondrial transcellular transport is a key example of such cellular …

Importance Preclinical and clinical studies have suggested the neuroprotective effect
ofPanax notoginsengsaponins (Xuesaitong soft capsules). However, robust evidence in …

Myocardial infarction (MI)-induced impaired cardiomyocyte (CM) mitochondrial function and
microenvironmental inflammatory cascades severely accelerate the progression of heart …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its
early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of …

Ischemic stroke is a common intravascular disease and one of the leading causes of death
and disability. The salidroside derivative SHPL-49, which we previously synthesized …

Background Information transmission between primary tumor cells and immunocytes or
stromal cells in distal organs is a critical factor in the formation of pre-metastatic niche …

Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders.
The primary active component of ginseng is ginsenoside, which has been classified into …

Cardiovascular disease (CVD), involving the pathological alteration of the heart or blood
vessels, is one of the main causes of disability and death worldwide, with an estimated 18.6 …

Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely
associated with migraines with an aura. Previously, it was thought that CSD depolarization …