The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit

MN Modi, Y Shuai, GC Turner - Annual review of neuroscience, 2020 - annualreviews.org
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …

Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlap** patterns of activity that represent sensory and motor information. Pattern …

The neuronal architecture of the mushroom body provides a logic for associative learning

Y Aso, D Hattori, Y Yu, RM Johnston, NA Iyer, TTB Ngo… - elife, 2014 - elifesciences.org
We identified the neurons comprising the Drosophila mushroom body (MB), an associative
center in invertebrate brains, and provide a comprehensive map describing their potential …

A connectome of a learning and memory center in the adult Drosophila brain

S Takemura, Y Aso, T Hige, A Wong, Z Lu, CS Xu… - elife, 2017 - elifesciences.org
Understanding memory formation, storage and retrieval requires knowledge of the
underlying neuronal circuits. In Drosophila, the mushroom body (MB) is the major site of …

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila

Y Aso, D Sitaraman, T Ichinose, KR Kaun, K Vogt… - elife, 2014 - elifesciences.org
Animals discriminate stimuli, learn their predictive value and use this knowledge to modify
their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes …

A neural algorithm for a fundamental computing problem

S Dasgupta, CF Stevens, S Navlakha - Science, 2017 - science.org
Similarity search—for example, identifying similar images in a database or similar
documents on the web—is a fundamental computing problem faced by large-scale …

Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics

V Croset, CD Treiber, S Waddell - Elife, 2018 - elifesciences.org
To understand the brain, molecular details need to be overlaid onto neural wiring diagrams
so that synaptic mode, neuromodulation and critical signaling operations can be considered …

[HTML][HTML] Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila

P Cognigni, J Felsenberg, S Waddell - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Recurrent connectivity is anatomically and functionally prevalent in fly memory
circuits.•Sustained reverberant activity is necessary for memory consolidation.•Feedforward …

Common principles for odour coding across vertebrates and invertebrates

KA Fulton, D Zimmerman, A Samuel, K Vogt… - Nature Reviews …, 2024 - nature.com
The olfactory system is an ideal and tractable system for exploring how the brain transforms
sensory inputs into behaviour. The basic tasks of any olfactory system include odour …

Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila

T Hige, Y Aso, MN Modi, GM Rubin, GC Turner - Neuron, 2015 - cell.com
Although associative learning has been localized to specific brain areas in many animals,
identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the …